Advances in the Immunopathogenesis of Multiple Sclerosis by Domencio Gambi,Allesandra Lugaresi,Paolo A. Muraro

By Domencio Gambi,Allesandra Lugaresi,Paolo A. Muraro

P.A. MURARO, A. LUGARESI, D. GAMBI the various pathological elements of a number of sclerosis (MS) lesions were identified for over a century. it's only lately, besides the fact that, that diverse styles of demyelination were associated with specified pathways of immune-mediated tissue destruction. particularly, the inter-individual heterogeneity of MS lesions has prompt that diversified mechanisms could act in several sufferers, accounting for the variety saw in medical path, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and reaction to immunomodulatory remedies. to supply an summary of the fundamental mechanisms potentially all in favour of MS lesion initiation and improvement, a global assembly was once equipped within the context of the once a year Congress of the Italian Neuroimmunology organization (AINI), held on the collage of Chieti, in Chieti Italy on 29 October 1998. The excessive typical of shows triggered us to file them in prolonged shape, to focus on fresh seasoned­ gress within the knowing of simple mechanisms maintaining MS immuno­ pathogenesis. A primary function within the attainable mechanisms resulting in myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. reviews at the myelin antigen-specific T phone repertoire have contributed major advances to our wisdom of autoimmunity (Chapters 1,2).

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